skor :) :: Remember, remember, the velvet November


node:	skor :)
template:	4
parent:	Inzerat pre teba
owner:	naberacka
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created:	03.05.2017 - 00:29:33

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ABSOLUT
KYBERIA

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Zijes v Berline?
Fajcis travu?
Nemas ziadne psychicke problemy?
Chces psychicke problemy?

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https://psychcentral.com/news/2013/12/10/harvard-marijuana-doesnt-cause-schizophrenia/63148.html

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pikachu, privolavam teba:
http://www.nature.com/articles/npjschz201525?WT
urcite genotypy su ultra nachylne na poskodenie. tu konkretne zistovali interakciu dvoch roznych alel a uzivania cannabis v asociacii so psychotickymi poruchami. nositelia dvoch risk alleles maju OR = 7.30 a z ktorych ti, co hulia denne, maju OR = 10.06 (OR = odds ratio, je pomer chorych/zdravych vystavenych vs. nevystavenych nejakemu vplyvu). adjustovane na rasu, socio-ekonomicke prostredie, abusus inych latok, ... toto nie su male cisla

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Nerozumiem ti

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Je to genetika a epidemiologia. Prelozene do bezneho jazyka: ked mas smolu, tak mas imho smolu :)

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trocha jednoduchsie, ale nie presne
ludia s urcitymi formami dvoch genov maju 7 nasobne vacsie riziko, ze sa u nich rozvinie psychoticka porucha. ak hulia denne, tak az 10 nasobne

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ako casty je ten genotyp v populacii?

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super otazka!

v doteraz zmeranej globalnej populacii je frekvencia tychto rizikovych alel 0.2149 a 0.4472.
https://www.snpedia.com/index.php/Rs1076560
https://www.snpedia.com/index.php/Rs2494732

pocetnost jedincov s co i len jednou rizikovou alelou mi po kratkom zamysleni a dlhsom pocitani vysla 0.8117
zda sa mi to kontraintuitivne, alebo som spravil niekde chybu a mal by som sa zamysliet dlhsie.
v kazdom pripade to bude viac ako polovica celosvetovej populacie.

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Ta studia mala kontrolovane mnohe, ale jedno zakladne sa mi zda nechali na "future research is needed" :) Nie je tam nikde kvantita uzivania, resp. som to v clanku nenasiel. Takto "od kolena" by som odhadol, ze lifetime daily users budu mat nie len frekvenciu, ale aj kvantitu vyssiu. A kedze na nie len na frekvencii, ale aj na kvantite asi zalezat bude...nie je tam ani presnejsie definovane "occasional".
Kazdopadne, kaslem na epidemoilogiu. Vonku konecne jar, beriem matros a moje clanky o bakteriach a idem si sadnut niekam do kaviarne :p

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ja si idem zabehat a beriem si do usi tohoto pana ;))
https://www.youtube.com/watch?v=NNnIGh9g6fA&list=PLD7E21BF91F3F9683

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DRD2 (rs1076560)
Riziková alela: "T"
frekvencia v EUR populácii: 15%
Globálne: 23%
http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=11:113283188-113284188;v=rs1076560;vdb=variation;vf=770927

AKT1 (rs2494732)
Riziková alela: "C"
frekvencia v EUR populácii: 44%
Globálne: 57%
http://grch37.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=14:105238692-105239692;v=rs2494732;vdb=variation;vf=1843118

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hej nist, uz som sa doklikal k tomu linku s clankom.

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A ta nachylnost sa prejavuje dominantne, staci ak je clovek heterozygot v tychto dvoch alelach, cize pravdepodobnost v nasej populacii cca 7%?
To imho nie je zanedbatelny vyskyt. Teraz este aka je baseline pre to zvysenie, teda prevalencia tych psychotickych poruch, ktorych riziko to zvysuje...

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je zvlastne, ze to autori nevypichli (mozno ich len limitovalo miesto v casopise)
v kazdom pripade ma teraz udivuje diskrepancia medzi studiami. kedze ludi s len jednou takou alelou je vacsina, preco to studie, ktore nerobili breakdown genotypu, nevideli?

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dobrá otázka

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jop, klasika, vacsinou potrebujes relativne aj absolutne cisla.

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Ako u koho. ;)

[mood] "That's how it ends, Doc. Not with a bang, or a whimper, but with a "thwack."

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Samozrejme, nie u kazdeho fajcenie travy sposobuje psychicke problemy.
U niekoho to moze byt chodenie do skoly. Alebo prace. Takze moc nechapem tvoju reakciu ;)

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prepac, ale 30g mesacne?
Gram denne, ako pise niekto vyssie, je dost jeba.

Nemusi priamo sposobovat schizofreniu. Zravky, strata motivacie a celkovo zivot v konstantnom marihuanovom opare (akokolvek prijemny) tiez povazujem za psychicky problem, namely zavislost.

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Radsej viac a vhodnou formou (vapo/kolaciky/palacinky) ako menej a domorodo (fajcit)
ale 30g mesacne? to je celkom dost.. hadam na dochodku :D

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30g mesacne a viac som hulieval par rokov a bolo to dokonale ♥
za prve som mal uplne inu toleranciu, cize jeden spek co mne stacil tak akorat na dve tri hodky (aj do prace v tom stave np, ofc nejsom neurochirurg) dokazal v klude odpalit kolektiv ludi co nehulili na cely vecer a to som ich fajcieval ofc viac denne.
preferoval som robit prijemne veci ako vencenie psa, vychadzky v prirode, hrat hudbu ale zvladal som normalne pracovat 12tky, komunikacia s ludmi, vybavovacky na uradoch.
zravky mavam a maval som aj pred hulenim aj teraz ked uz tolko nehulim, motivacia podla toho o co islo.
negativum pre mna bolo ze som viac zabudal, resp. niektore veci mi prisli ako nepodstatne aj ked mozno boli a preto som ich neriesil.
teraz hulim malo, 5g mi vydrzi niekedy viac ako mesiac a nejak v tom nevidim rozdiel, akorat vtedy som bol viac "ukludneny" :)

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este potom je zaujmavy factor to, ako posobis na inych

akoze komunikovat vo vztahu alebo v robote s niekym, kto je nonstop napadrt je na slucku

Papagaje mi uhynuli v 2015.

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ja nech som akokoľvek na padrť, obvykle ľudia tvrdia, že na mne nič nevidno, a sú prekvapení, keď im to poviem. akurát na koncertoch mi údajne začalo byť konečne rozumieť, čo spievam.

×÷ßßß$ˇ~[☼◙ş→☻ü84ó♀ÇüŮń§►♫☺♀♂ć☺<ˇ

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ale ty mas taku defaultne napadrt tvar :)

ale ne, nesnazim sa generalizovat
len poznam takych, co prehulia 200-300e mesacne a komunikovat s nimi je casto utrpenie

Papagaje mi uhynuli v 2015.

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defaultne napadrt tvar

krasny kompliment :D

don't take my kindness as a sign of weakness

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urcite, to je mozno dalsi negativny faktor, ze zit nonstop v opare moze byt sebecke.
ale v robote napr. 99% ludi nevedelo ze hulim, robotu som si robil dobre a neboli ziadne staznosti. mozno aj pre tu posunutu toleranciu

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no ale veď to predsa nesfajčíš sám, ale s kamošmi

×÷ßßß$ˇ~[☼◙ş→☻ü84ó♀ÇüŮń§►♫☺♀♂ć☺<\ˇ

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V mojom okruhu poznam ludi ktori kludne vykurja 30g,+/mesiac (a to uplne abstrahujem moznost ze medzi uzivatelmi mozu byt fanusikovia vaporizacie, kolacikov a extraktov ktore si mozes z tejto davky pripravit) a ani jeden symptom tebou popisany sa u nich neprejavil.
Takze?
Kto sa citi a moze nech sa prihlasi a prispeje k pochopeniu dosledkov dlhodobeho uzivania.

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Ja som fajcil 30g+/mesiac a bolo to peklo. Zavislost, brko obcas hned rano, v praci peklo, kratkodoba pamat uplne odpisana, hrozne spomaleny. A samozrejme ked je zle obdobie (co byvavalo) tak hulivo fakt zhorsuje depresie, plus paranoje a podobne. Nie ze by depresie boli z hulenia, ale nepomahalo to teda ani trochu. To uz ale su psychicke problemy, cize na tu studiu by som nebol vhodny kandidat.

Ked som prestal, postupne zacala pribudat inteligencia a zlepsovat sa pamat. Velka skoda ze to takto dopadlo, lebo zahulit si iba obcas by bolo fajn, ale obavam sa ze pokial sa do toho pekla nechcem vratit tak zo mna bude musiet byt do konca zivota abstinent. Este ze su papiere :)

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ja tiez poznam v mojom okruhu par takych ludi a viem, ze niektori maju problemy. imo trava dlhodobo denne neni v pohode, myslim ze to je ako s chlastom: dobry sluha, ale zly pan.

chvalabohu v tych par clankoch, co som k tomu pozrela sa vsade hovori, ze po withdrawal - ked sa prestane brat, tak do max mesiaca vsetko v cajku, receptory, pamet atak. akurat je problem, ze niektori nikdy neprestanu.

...

As early as the late 19th century, the Indian Hemp Drugs
Commission reported that heavy cannabis use was associated with
apathy, defined as reduced motivation for goal-directed behavior.
However, it was only after the marked increase in cannabis use of
the1960s that the amotivational effects of chronic cannabis use were
linked to impairments in learning and sustained attention. The term
cannabis amotivational syndrome was proposed by McGlothlin and
West, who characterized it as apathy and diminished ability to concentrate,
follow routines, or successfully master new material. While
there has always been some controversy around the need for defining
such a distinct phenotype, there is evidence that long-term
heavy cannabis use is associated with educational underachievement and
impaired motivation, which have been proposed to be potential
mediators of poorer functional outcomes.
https://www.ncbi.nlm.nih.gov/pubmed/26842658

Like most addictions, cannabis addiction is often comorbid
with other mental health problems. Epidemiological
evidence indicates a possible association between
regular cannabis use and the development of anxiety and depression
https://www.nature.com/nrn/journal/v17/n5/full/nrn.2016.28.html

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netreba prestať úplne, stačí obmedziť

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presne toto, našťastie to nepoškodí človeka dlhodobo, keď prestane/obmedzí

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travicka, kvetinky...until it's not, pre niektorych. nie je to len o motivacii a pamati
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169519/
It is also usually highly recurrent [depression], with at least 50% of those who recover from a first episode of depression having one or more additional episodes in their lifetime, and approximately 80% of those with a history of two episodes having another recurrence (American Psychiatric Association, 2000; Kupfer, Frank, & Wamhoff, 1996; Post, 1992)