PSYCHE DELIC SCIENCE :: Remember, remember, the velvet November


node:	PSYCHE DELIC SCIENCE
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parent:	Veda a technologie
owner:	Mju
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created:	17.09.2014 - 19:22:09
updated:	17.05.2017 - 13:23:13

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ABSOLUT
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PSYCHEDELIC
SCIENCE
Fórum venované výskumu a novinkám v oblasti psychedélie a jej využitia pre zlepšenie zdravia a kvality života.

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Slovenská psychedelická spoločnosť (SAPAS)
Web SAPAS

Odporúčané linky:

MAPS - Multidisciplinary Association of Psychedelic Studies
http://www.maps.org/
https://twitter.com/mapsnews
https://www.facebook.com/mapsmdma
http://www.youtube.com/user/mapsmdma

ZENDO project
http://www.maps.org/resources/responding_to_difficult_psychedelic_experiences/
https://www.facebook.com/zendoproject/info

ČESKÁ PSYCHEDELICKÁ SPOLEČNOST
https://www.facebook.com/czeps.org/?fref=ts
http://www.czeps.cz/

GLOBAL IBOGAINE THERAPY ALLIANCE
http://www.ibogainealliance.org/
https://www.facebook.com/ibogainealliance/

ICEERS - Interantional Centre for Ethnobotanical Education, Research and Service
http://www.iceers.org/
https://www.facebook.com/ICEERS/

PRISM - Psychedelic Research in Science and Medicine
http://www.prism.org/
https://www.facebook.com/PRISMNews/

OPEN Foundation
http://www.stichtingopen.nl/
https://www.facebook.com/stichting.open/

reset.me - http://reset.me/ | https://www.facebook.com/resetmenews/
open mind trips (fórum) - http://openmindtrips.com/ | https://www.facebook.com/openmindtrips/
psychedelic times - http://psychedelictimes.com/ | https://www.facebook.com/ThePsychedelicTimes/
drug reporter - http://drogriporter.hu/en

Príbuzné fóra:

Drugs - Harm Reduction
DMT ihrisko
LSD PSYCHOTHERAPY
MARIHUANA a MEDICINA
halucinogeny
LSD
War On DRUGS
Drogová politika - trestné právo,polícia, súdy, médiá
Výzkum psychedelik ožívá.. takové
malé overview 2014..

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Significance
Psychedelic compounds, such as lysergic acid diethylamide (LSD), can promote the growth of atrophied cortical neurons, which is relevant to the treatment of numerous brain conditions. However, their hallucinogenic properties have limited their adoption as medicines and preclude their use in certain patient populations, such as those with schizophrenia or a family history of psychosis. By transposing only two atoms, we have created JRT, an exceptionally potent analogue of LSD with lower hallucinogenic potential, improved pharmacological selectivity, and the ability to produce a wide range of therapeutic effects. Our work highlights the potential of rationally designed, nonhallucinogenic analogues of psychedelics for treating diseases where the use of psychedelics is contraindicated.

Abstract
Decreased dendritic spine density in the cortex is a key pathological feature of neuropsychiatric diseases including depression, addiction, and schizophrenia (SCZ). Psychedelics possess a remarkable ability to promote cortical neuron growth and increase spine density; however, these compounds are contraindicated for patients with SCZ or a family history of psychosis. Here, we report the molecular design and de novo total synthesis of (+)-JRT, a structural analogue of lysergic acid diethylamide (LSD) with lower hallucinogenic potential and potent neuroplasticity-promoting properties. In addition to promoting spinogenesis in the cortex, (+)-JRT produces therapeutic effects in behavioral assays relevant to depression and cognition without exacerbating behavioral and gene expression signatures relevant to psychosis. This work underscores the potential of nonhallucinogenic psychoplastogens for treating diseases where the use of psychedelics presents significant safety concerns.

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Asi ste už viacerí zachytili, ale pre úplnosť.
V Česku povolili terapiu s psilocybínom (mimo štúdie) pre rezistetnú depresiu, existenciálnu úzkosť a myslm, že aj pri PTSD.

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Možno už viacerí viete.
FDA zamietla MDMA asistovanú terapiu pre PTSD; napriek velmi dobrým výsledkom. Kvôli psychoterapii, je to tých schvalovatelov black box (boli totiž aj nejaké prúsery)
https://www.nature.com/articles/d41586-024-01622-3

Naopak, holanďania ju odporúčajú.
https://www.politico.eu/article/dutch-panel-recommends-mdma-ecstasy-post-traumatic-stress-disorder/

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udajne je za tym sabotaz psymposie https://www.nytimes.com/2025/02/04/health/fda-mdma-psychedelic-therapy-psymposia.html

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je napr v CR nejaka terapia/liecba s MDMA povolena/realizovana?

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Myslím, že mdma nie.
Psilocybin (vramci štúdie)a ketamin.(aj mimo štúdie)

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narazil som na nieco taketo
https://czeps.org/

neviem, ci tu ma niekto skusenosti/prehlad - zrejme je nemozne odpovedat pausalne, pocet sedeni a tak asi zavisi, ako velmi je to financne narocne?

any ideas?

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dakujem, neviem preco som si myslel, ze mdma ano

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tltw; Nie je dôležité, čo zažiješ, ale ako to integruješ do svojho každodenného života (Huxley)

Veľkú radosť mi spravilo toto video.
Michael Vančura je frajer najfrajerskejší!

Pred šiestimi rokmi som si ho dopriala ako sprievodcu.
Robili sme najskôr tú body therapy ako predprípravu.
Potom holotropné dýchanie. Mlôžem iba odporučiť.
Plus rokmi skúseností vycíti a reže presne.
Doteraz mi zarezonujú nejaké jeho postrehy, čo mi dal počas tých pár stretnutí.

Napísla so mu, poďakovala a pokúšam sa objednať na pokračovaie :)

všetci zomrieme <3

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Ahojte,
buduci utorok opat poriadame s Beyond Psychedelics skupinove sedenie s temou integracia psychedelickeho zazitku.
Pridajte sa k nam, ak by ste sa chceli porozpravat o tom, co ste zazili a ako sa k tomuto zazitku vztahovat v beznom zivote.
Ak poznate niekoho, koho by akcia mohla zaujat, budem rad za kazde zdielanie

FB event tu

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Trochu mainstream infotainmentu.

Lieb sein.

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a tu je kriticky response od psymposie, tj. ludi, s ktorymi tento diel briefoval:
https://www.psymposia.com/magazine/john-oliver-last-week-tonight-psychedelic-assisted-therapy/

perfektne zhrnute, oi:
Psychedelic science is limited by small sample sizes and methodological issues that cast doubt on flashy efficacy numbers. Many of the most prominent clinical trials failed to control for variability (dosage, therapeutic protocols, etc.) across sites and sessions, which means that their studies are not able to distinguish between effects caused by the drug and effects caused by other variables. Questionable research practices that have compromised research in other fields are happening in psychedelic research, including switching outcome measures and p-hacking to produce the appearance of significant results. There is also a severe lack of long term (or even medium term) follow-up data, along with a lack of attention to overall quality of life. In some studies, participants who were labeled as “cured” actually deteriorated as a result of being in the trial.

Many of the dominant assumptions about psychedelic-assisted therapy (PAT) are unscientific. Psychedelic therapists and “coaches” often promote untested, magico-religious beliefs. There is no consensus on what constitutes the clinical practice of psychedelic therapy. Instead, fringe and “woo” methods and ideologies pervade the field. Such ideas have already been used to cover up harms and to widely promote unsafe models for use.

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https://www.psymposia.com/powertrip/
dost desive veci sa deju pod vedenim istych terapeutov

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How humans developed from our Homo erectus ancestors, doubling our brain capacity within a space of around 200,000 years - which in evolutionary terms is the blink of an eye - is one mystery that people have sought to find an answer for.

...

He thought that when the environment in Africa changed, Homo erectus was compelled to seek out new food sources, such as magic mushrooms. The impacts of the mushrooms caused Homo erectus's thinking processes to rearrange quickly.He thought that when the environment in Africa changed, Homo erectus was compelled to seek out new food sources, such as magic mushrooms. The impacts of the mushrooms caused Homo erectus's thinking processes to rearrange quickly.
https://www.sciencetimes.com/articles/41518/20221225/stoned-ape-theory-explained-is-this-hypothesis-on-evolution-valid.htm

(neviem či dobré fórum, ale zaujímali by ma názory)

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To znie ako taka ta naivna lamarckovska evolucia -- zirafa ma dlhy krk, lebo ho stale natahuje a to sa potom nejak prenesie na deti. Od cias Darwina ale vieme, ze na smerovanie evolucie potrebujes hlavne selekcny tlak, co ti imho huby nemaju ako poskytnut.

Tazko dohladat povodny clanok z toho, co si linkol, tak neviem, ci to ten povodny autor myslel tak.

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ešte tu máme epigenetiku, ale niečo mi hovorí, že ak by toto mala byť pravda, potom by to muselo platiť aj pre množstvo iných zvierat:)

×÷ßßß$ˇ~[☼◙ş→☻ü84ó♀ÇüŮń§►♫☺♀♂ć☺<\ˇ

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hmm? http://www.animalcognition.org/2015/05/16/animal-drug-use/

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skôr je reč vyložene o psychedelikách, a tie konzumuje kadekto, napr psychedelické huby žerie hocičo od slimákov až po soby

×÷ßßß$ˇ~[☼◙ş→☻ü84ó♀ÇüŮń§►♫☺♀♂ć☺<\ˇ

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ked sa nejakemu druhu otvori nova ekologicka nika, alebo cele nove prostredie, tak v pomerne (na evolucne pomery) velmi kratkom case dochadza k rapidnym zmenam, casto k rozvetveniu druhov, ktore sa specializuju na konkretne oblasti. v tomto pripade druh homo siel sice evolucne nestandardnou, ale z hladiska prezitia druhu vyhodnejsou cestou. kedze sa mu rapidne zlepsovali kognitivne schopnosti, mohol sa univerzalizovat a ovela lepsie sa prisposobovat zmenam prostredia.

konzumacia hub moze mat velmi roznorode pozitivne efekty na jednotlivcov, ale zatial sa nezda, ze by sa mexicanom, u ktorych to ma tradiciu siahajucu tisice rokov dozadu, nejako rapidne zvacsovali hlavy.

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Keď som čítala latinsko-americký magický realizmus, mala som pocit, že ich hlavy majú najmenej kilometer. Oni pojedli drogy z celej zemegule a boli prudko invenční.

Edit: Vôbec autori latinského sveta sú o level šibnutejší, než všetci ostatní. Aj sa zle prekladajú do Slovenčiny, lebo sú dosť komplikovaní.

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Haha toto je vtipne, 22.12. Som v Cvernovke chutnal “koralovec” a chlapik mi vravi ze obsahuje latky stimulujuce obnovu mozgu. 23.12. som bol na obede so sefkou bratislavskej ZOO a vravela mi, ze je vonku zaujimavy paper o vplyve konzumacie aktivnych hub na akceleraciu vyvoja nasho druhu. A teraz to citam tu:)

Jaj a este - vcera som mal na veceru uzasnu cerstvu hlivu, len tak v rure s olivacom a cesnakom a zemiakmi. Uzasne jedlo ked je dobra surovina. Ale mozog ziadne zmeny.

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14. 11. 2022, KLECANY – Slibné výsledky přinesla druhá část velké mezinárodní studie COMPASS Pathways, která se zabývá léčbou rezistentní deprese pomocí psilocybinu a na které se podílejí také vědci z Národního ústavu duševního zdraví (NUDZ). Vědci zkoumali optimální dávkování a možné vedlejší účinky. U části pacientů trvalo zlepšení příznaků deprese i 12 týdnů po podání látky. Výsledky byly nyní publikovány v prestižním The New England Journal of Medicine. V chystané třetí fázi budou vědci zkoumat účinky po opakované dávce.
https://www.nudz.cz/pro-media/tiskove-zpravy/nadejna-mezinarodni-studie-lecby-rezistentni-deprese-psilocybinem-probiha-take-v-cesku-vedci-spousteji-dalsi-a-hledaji-dobrovolniky

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Minulý týždeň boli zverejnené výsledky očakávanej štúdie Dr. Michaela Bogenschutza a jeho tímu. Aj pri terapii ťažkej alkoholovej závisloti sa ukázali robustné terapeutické účinky psilocibínu (dve sedenia) v kombinácii s psychoterapiou. Išlo o dvojito zaslepenú randomizovanú diphenhydramínom kontorlovanú štúdiu na 93 participantoch.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625?guestAccessKey=ab1fc0a8-8930-47b3-9d4b-831ee984c884&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082422&fbclid=IwAR1DgoxxcajFgUf45GPu4Cm46spFlauucsV8y7zcPXm-A3gjayQTJml-suo

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In this new study, the NYU researchers noted virtually every subject correctly guessed whether they were given psilocybin or placebo. By the second drug session, nearly 95 percent of participants had guessed correctly which group they had been assigned.
https://newatlas.com/health-wellbeing/psilocybin-alcoholism-placebo-problem-psychedelic-science/

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Minulý týždeň boli zverejnené výsledky očakávanej štúdie Dr. Michaela Bogenschutza a jeho tímu. Aj pri terapii ťažkej alkoholovej závisloti sa ukázali robustné terapeutické účinky psilocibínu (dve sedenia) v kombinácii s psychoterapiou. Išlo o dvojito zaslepenú randomizovanú diphenhydramínom kontorlovanú štúdiu na 93 participantoch.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625?guestAccessKey=ab1fc0a8-8930-47b3-9d4b-831ee984c884&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082422&fbclid=IwAR1DgoxxcajFgUf45GPu4Cm46spFlauucsV8y7zcPXm-A3gjayQTJml-suo

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investigativny pohlad do psychedelickej sceny
https://open.spotify.com/show/7dj2XnCMxGpK8W3tGWjiqw

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Dvojito zaslepená randomizovaná kontrolovaná štúdia (zlatý štandard klinických štúdií) porovnávala skupinu depresívnych ľudí užívajúcich psilocybín s tými, ktorí užívali existujúce antidepresívum escitalopram. Ide o prvú štúdiu svojho druhu.
Podľa stupníc hodnotenia depresie mal psilocybín celkovo väčší vplyv na duševnú pohodu. Kým na psychedelikum klinicky odpovedalo 70 percent pacientov, pri štandardnom antidepresíve to bolo iba 48 percent z vybranej skupiny ľudí.
https://dennikn.sk/2869920/psychedelikum-v-hubach-ma-potencial-preprogramovat-mozog-a-liecit-depresiu/?ref=list?ref=mpm

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citam The Way of the Psychonaut od Stanislava Grofa a toto je teda riadna temnotka:

"
This mechanism can be observed very clearly in experiential work. In holotropic states, the contentof the experience, the perception of the environment, and the behavior of the client are determined ingeneral terms by the COEX system that dominates the session and, more specifically, by the layer ofthis system that is momentarily emerging into consciousness. All the characteristics of COEX systemscan best be demonstrated by a practical example. I have chosen, for this purpose, Peter, a 37-year-oldtutor who had been intermittently hospitalized and unsuccessfully treated in our department in Pragueprior to his psychedelic therapy.At the time we began with the experiential sessions, Peter could hardly function in his everyday life.He was almost constantly obsessed with the idea of finding a man with certain physical characteristics,preferably dressed in black clothes. He wanted to befriend this man and tell him about his urgent desireto be locked in a dark cellar and be exposed to various diabolic physical and mental tortures. Unable toconcentrate on anything else, he wandered aimlessly through the city, visiting public parks, lavatories,bars, and railroad stations searching for the “right man.”He succeeded on several occasions to persuade or bribe various men who met his criteria to promiseor do what he asked for. Having a special gift for finding persons with sadistic traits, he was almostkilled twice, several times seriously hurt, and once robbed of all his money. On those occasions, wherehe was able to experience what he craved, he was extremely frightened and actually strongly disliked thetortures. In addition to this main problem, Peter suffered from suicidal depression, impotence, andinfrequent epileptiform seizures.Reconstructing his history, I found out that his major problems started at the time of hisinvoluntary employment in Germany during World War II. The Nazis used people brought toGermany from occupied territories for work in places threatened by air raids, such as foundries andammunition factories. They referred to this form of slave labor as Totaleinsetzung. At that time, two SSofficers repeatedly forced him at gunpoint to engage in their homosexual practices. When the war wasover, Peter realized that these experiences created in him a strong preference for homosexual
intercourse experienced in the passive role. This gradually changed into fetishism for black male clothesand finally into the complex obsessive-compulsive masochistic behavior described above.Fifteen consecutive psychedelic sessions revealed a very interesting and important COEX systemunderlying his problems. In its most superficial layers were Peter’s more recent traumatic experienceswith his sadistic partners. On several occasions, the accomplices he recruited actually bound him withropes, locked him in a cellar without food and water, and tortured him by flagellation andstrangulation, according to his wish. One of these men hit him on his head, bound him with a string,and left him lying in a forest after stealing his money.Peter’s most dramatic adventure involved a man who claimed he had just the kind of cellar Peterwanted in his cabin in the woods and promised to take him there. When they were traveling by train tothis man’s weekend house, Peter was struck by his companion’s strange-looking bulky backpack. Whenthe latter left the compartment and went to the bathroom, Peter stepped up on the seat and checkedthe suspicious baggage. He discovered a complete set of murder weapons, including a gun, a largebutcher knife, a freshly sharpened hatchet, and a surgical saw used for amputations. Panic-stricken, hejumped out of the moving train and suffered serious injuries. Elements of the above episodes formedthe superficial layers of Peter’s most important COEX system.A deeper layer of the same system contained Peter’s memories from the Third Reich. In the sessionswhere this part of the COEX constellation manifested, he relived his experiences with the homosexualSS officers in detail, with all the complicated feelings involved. In addition, he relived several othertraumatic memories from World War II and dealt with the entire oppressive atmosphere of this period.He had visions of pompous Nazi military parades and rallies, banners with swastikas, ominous gianteagle emblems, scenes from concentration camps, and many others.Then came layers related to Peter’s childhood, particularly those involving punishment by hisparents. His alcoholic father was often violent when he was drunk and used to beat him with a largeleather strap. His mother’s favorite method of punishing him was to lock him into a dark cellar withoutfood for long periods of time. Peter recalled that throughout his childhood, she always wore blackdresses; he did not remember her ever wearing anything else. At this point, he realized that one of theroots of his obsession seemed to be craving suffering that would combine elements of punishmentinflicted on him by his parents.However, that was not the whole story. As we continued with the sessions, the process deepened andPeter confronted the trauma of his birth with all its biological brutality. This situation had all theelements that he expected from the sadistic treatment he was so desperately trying to receive: darkenclosed space, confinement and restriction of physical movement, and exposure to extreme physicaland emotional tortures. Reliving the trauma of his birth finally resolved his difficult symptoms to suchan extent that he could once again function in life."

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The way you see yourself and the world is a controlled hallucination, Seth argues. Rather than passively perceiving our surroundings, our brains are constantly making and refining predictions about what we expect to see; in this way, we create our world.

Reality, Seth believes, is the hallucination we can all agree on.

Some aspects of perception are more illusory than others. Our experience of ourselves, as having an enduring, stable identity over time, is a useful illusion. As is our perception of free will: we believe we are acting freely when we follow our own beliefs, goals or desires – but we can’t freely choose those beliefs, goals or desires. The purpose of consciousness, of all these hallucinations, is to keep us alive. When we die, it will be extinguished. Seth believes other animals are conscious, but doesn’t think artificial intelligence ever will be.
https://www.newstatesman.com/science-tech/2022/02/is-reality-a-hallucination-the-neuroscientist-anil-seth-thinks-so

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Dekonštrukcia jedinej ilúzie, že psychedeliká majú vlastnú inherentnú agendu a nie sú len nešpecifické amplifikatory setu a settingu vo Frontiers:
"Recent media advocacy for the nascent psychedelic medicine industry has emphasized the potential for psychedelics to improve society, pointing to research studies that have linked psychedelics to increased environmental concern and liberal politics. However, research supporting the hypothesis that psychedelics induce a shift in political beliefs must address the many historical and contemporary cases of psychedelic users who remained authoritarian in their views after taking psychedelics or became radicalized after extensive experience with them. We propose that the common anecdotal accounts of psychedelics precipitating radical shifts in political or religious beliefs result from the contextual factors of set and setting, and have no particular directional basis on the axes of conservatism-liberalism or authoritarianism-egalitarianism. Instead, we argue that any experience which challenges a person's fundamental worldview—including a psychedelic experience—can precipitate shifts in any direction of political belief. We suggest that the historical record supports the concept of psychedelics as “politically pluripotent,” non-specific amplifiers of the political set and setting. Contrary to recent assertions, we show that conservative, hierarchy-based ideologies are able to assimilate psychedelic experiences of interconnection, as expressed by thought leaders like Jordan Peterson, corporadelic actors, and members of several neo-Nazi organizations."
https://www.frontiersin.org/articles/10.3389/fpsyg.2021.733185/full

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Fascism can take many forms and vary in degree—hence the term “crypto-fascist,” which refers to those concealing fascist sympathies or “hiding their power level” (ContraPoints, 2017)[...]

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