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Over 80% of subjects receiving MDMA-assisted psychotherapy in a pilot study no longer met the criteria for PTSD. A long-term follow-up study revealed that overall benefits were maintained an average of 3.8 years later. http://youtu.be/BNxuRs6tTuw
10250133_10152133198628481_3371812697262341238_n.png


Research indicates that MDMA-assisted psychotherapy could be a promising future treatment for people suffering from posttraumatic stress disorder (PTSD).
Using Ecstasy To Cure PTSD: Psychedelic Gives War Veterans A New Lease On Life
http://www.medicaldaily.com/using-ecstasy-cure-ptsd-psychedelic-gives-war-veterans-new-lease-life-280928

In Switzerland, the first controlled trial of the drug in more than 40 years found that it eased anxiety in people nearing the end of their lives.
LSD, Reconsidered for Therapy | NY Times
http://www.nytimes.com/2014/03/04/health/lsd-reconsidered-for-therapy.html?smid=tw-share
1920419_10152016333498481_242416565_n.jpg

The Bristol Post highlights emerging research into psilocybin, MDMA, and ketamine as treatments for addiction, depression, PTSD, obsessive compulsive disorder, and other conditions.
Bristol research: Danger drugs 'could have potential to save lives'
http://www.bristolpost.co.uk/ResearchDanger-drugs-potential-save-lives/story-21027391-detail/story.html#SIxafI6OSHlvd5xu.99

Scientific American explores the history of research into the potential medical benefits of LSD, MDMA, psilocybin, and marijuana, highlighting how these substances hold promise for treating people suffering PTSD, cluster headaches, obsessive compulsive disorder, and other conditions.
End the Ban on Psychoactive Drug Research | Scientific American
http://www.scientificamerican.com/article/end-the-ban-on-psychoactive-drug-research/


Nature explores the breaking down of political interference that has been preventing researchers from effectively studying the medical potential of marijuana.
Federal red tape ties up marijuana research | Nature
http://www.nature.com/news/federal-red-tape-ties-up-marijuana-research-1.14926
safe_image.php?d=AQAUks5su40Ey-lH&w=377&h=197&url=http%3A%2F%2Fi.huffpost.com%2Fgen%2F1777231%2Fthumbs%2Fo-MEDICAL-MARIJUANA-facebook.jpg&cfs=1

Anecdotal reports suggest that cannabidiol (CBD), a non-psychoactive compound found in marijuana, can significantly reduce epileptic seizures, inflammation, and pain.
A low-THC strain of cannabis grown in Colorado may help treat severe epilepsy
http://www.5280.com/healthandwellness/magazine/2014/04/tangled-web?page=full
safe_image.php?d=AQAK5H4mmL-7xUAl&w=377&h=197&url=http%3A%2F%2Fwww.5280.com%2Fsites%2Fdefault%2Ffiles%2Fstyles%2Fcrop_630x414%2Fpublic%2F96-97.jpg%3Fitok%3DNybrYT1K&cfs=1&sx=0&sy=21&sw=630&sh=329

In anticipation of upcoming marijuana research, the government will increase their production of research-grade marijuana from 21 kilograms per year to 650 kilograms— a nearly 3,000% increase.
The feds are looking to score 650 kilos of weed
http://www.vox.com/2014/5/2/5676370/the-feds-just-boosted-how-much-marijuana-they-grow-for-research




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SYNAPSE CREATOR
 lubomier.sk      10.11.2017 - 20:46:19 [6K] , level: 1, UP   NEW  HARDLINK
Príjemné videjko z refresheru...

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SYNAPSE CREATOR
 demian      07.12.2016 - 14:09:36 [3K] , level: 1, UP   NEW  HARDLINK
The Global Ayahuasca Project is a multidisciplinary research project being undertaken by researchers at the University of Melbourne, Australia, State University of Campinas, and Universidade Federal de São Paulo, Brazil.

The project aims to increase understanding of the drinking of ayahuasca in different contexts around the globe. It will explore motivations and contexts of drinking, reported effects on health and well-being, and any potential risks.

If you have drunk ayahuasca please join the project - share your experiences in the first Global survey of ayahuasca drinking and help build understanding of the effects of this sacramental tea on the lives of those who consume it.

The survey is anonymous and collects data over an encrypted connection. It will take around 35 minutes and needs to be completed in one sitting. The survey is initially available in English, with Portuguese and Spanish versions to follow.
http://www.globalayahuascaproject.org/

0000010100063533052119940758506608177813
SYNAPSE CREATOR
 Thunder Perfect Mind      02.07.2016 - 21:25:21 (modif: 02.07.2016 - 21:26:54) [3K] , level: 1, UP   NEW  HARDLINK !!CONTENT CHANGED!!
LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality

a Vox ma zhrniak: The fascinating, strange medical potential of psychedelic drugs, explained in 50+ studies

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Thunder Perfect Mind
 Thunder Perfect Mind      17.05.2016 - 13:39:54 (modif: 17.05.2016 - 13:40:20) [5K] , level: 1, UP   NEW !!CONTENT CHANGED!!
Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Findings Psilocybin’s acute psychedelic effects typically became detectable 30–60 min after dosing, peaked 2–3 h after dosing, and subsided to negligible levels at least 6 h after dosing. Mean self-rated intensity (on a 0–1 scale) was 0·51 (SD 0·36) for the low-dose session and 0·75 (SD 0·27) for the high-dose session. Psilocybin was well tolerated by all of the patients, and no serious or unexpected adverse events occurred. The adverse reactions we noted were transient anxiety during drug onset (all patients), transient confusion or thought disorder (nine patients), mild and transient nausea (four patients), and transient headache (four patients). Relative to baseline, depressive symptoms were markedly reduced 1 week (mean QIDS difference –11·8, 95% CI –9·15 to –14·35, p=0·002, Hedges’ g=3·1) and 3 months (–9·2, 95% CI –5·69 to –12·71, p=0·003, Hedges’ g=2) after high-dose treatment. Marked and sustained improvements in anxiety and anhedonia were also noted.

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killya
 killya      17.05.2016 - 19:16:10 , level: 2, UP   NEW
psilocybin ten 5-htt receptor aktivuje nejako dlhodobejsie alebo len ked je psilo v organizme, tak 5-htt bude aktivny?

According to standard criteria for determining
remission (eg, a score of ≤9 on the BDI), eight (67%) of
the 12 patients achieved complete remission at 1 week
and seven patients (58%) continued to meet criteria for
response (50% reduction in BDI score relative to
baseline) at 3 months, with five of these (42%) still in
complete remission (figure 4, table 3). STAI-T anxiety
scores were also significantly reduced at 1 week and
3 months post-treatment, as were SHAPS anhedonia
scores for 1 week and 3 months post-treatment (table 3).


to remission je, ze jednorazove pouzitie (x denna/mesacna kura raz za zivot) a uz nikdy (hypoteticky) by nemali anhedonizmus?

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Thunder Perfect Mind
 Thunder Perfect Mind      17.05.2016 - 20:49:54 [4K] , level: 3, UP   NEW
Priame posobenie na receptory je myslim kratkodobe, niekolko hodin, max. desiatok hodin.

Sucasne chapanie posobenia psychedelik je, velmi zhruba, ze rozsynchronizuju (oslabia) beznu mozgovu komunikaciu (Default Mode Network), rozbiju zazite spojenia, a 'prepoja' casti mozgu ktore zvycajne nekomunikuju. Toto sa stane jednorazovo, ale ukazuje sa ze kym 'bezne fungovanie' sa vrati 'do normalu' pomerne rychlo, niektore prepojenia sa oslabia resp. neobnovia na dlho, niektore vzniknu nanovo. Nikdy je silne slovo, ale aj pri inych studiach boli efekty (jednorazoveho pouzitia) minimalne niekolkomesacne (a zrovna na anhedoniu funguje tusim aj ketamin, ktory posobi zrejme uplne inak).

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evad
 evad      18.05.2016 - 11:14:51 [1K] , level: 4, UP   NEW
pekne zhrnute

bolo by zaujimave (z psycho hladiska) sa pozriet ako to vplyva na autobiograficku pamet a ako sa meni (narativna) identita.

este mi tam k tomu prislo zaujimave aj toto
Psychedelics are known to promote suggestibility, which
might have further enhanced positive outcomes. ... From a more
pragmatic perspective, if expectancy or suggestibility are
found to be influential in the context of psychedelic
therapy, they could be treated as exploitable components
of the treatment model rather than confounding variables


a s tym spojena je urcite extremne dolezita motivacia ku zmene

000001010006353305211994075850660815073008150958081509880815120008151234
Thunder Perfect Mind
 Thunder Perfect Mind      18.05.2016 - 12:21:52 [1K] , level: 5, UP   NEW
Podla toho co vieme o DMN tam ten vplyv bude. Ci myslis nieco ako zachytit stav autobiografickej pamati 'pred' a 'po' a porovnat? Hej to by mohlo byt velmi zaujimave.

S tou motivaciou ku zmene, ak myslis nejaku externu alebo umyselnu, vedomu... neviem, podla mna motivacia ku zmene je tam vnutorna / vyplyvajuca zo sposobu fungovania tych latok. Trochu vychadzajuc z tohto - stratis istotu v prior knowledge/confidence/certainty, nemas inu moznost ako niektore veci 'riesit' odznova.

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evad
 evad      18.05.2016 - 19:09:38 , level: 6, UP   NEW
ano nieco take som myslela, aj ked to ide fakt tazko - dalo by sa spravit napr standardizovane life story interview pred a po (po par mesiacoch ked sa to usadi)

jednak by tam mal byt znatelny vplyv na tzv autobiographical reasoning, ako si ludia vysvetluju niektore veci vo svojom zivote, atribucie atp. (to bude ako pises "niektore veci riesit odznova"); a pri depresii dochadza aj k tzv overgeneral memory efektu, tj clovek si vybavuje menej konkretnych spomienok a viac pri spominani "generalizuje"... to su vsetko veci, ktore meni aj psychoterapia, len to dost dlho trva.

a s tou motivaciou som mala na mysli obycajnu old skul vedomu motivaciu, ale asi by som sa do toho teraz zbytocne zaplietla, lebo samotna depresia to cele este dost komplikuje

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killya
 killya      17.05.2016 - 20:55:47 , level: 4, UP   NEW
cool, dik

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Thunder Perfect Mind
 Thunder Perfect Mind      07.05.2016 - 19:36:04 [2K] , level: 1, UP   NEW
LSD-induced entropic brain activity predicts subsequent personality change
Neural correlates of the LSD experience revealed by multimodal neuroimaging.
Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution
a este zopar dalsich vyslo

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Thunder Perfect Mind
 Thunder Perfect Mind      11.04.2016 - 22:41:27 (modif: 12.04.2016 - 00:39:16), level: 1, UP   NEW !!CONTENT CHANGED!!
http://medicalxpress.com/news/2016-04-brain-lsd-revealed-scans-drug.html

e: David Nutt @Nature: Brain scans reveal how LSD affects consciousness

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evad
 evad      13.04.2016 - 20:49:12 (modif: 13.04.2016 - 20:50:14), level: 2, UP   NEW !!CONTENT CHANGED!!


https://www.theguardian.com/science/video/2016/apr/12/brain-scans-lsd-acid-trip-imperial-college-london-video

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Thunder Perfect Mind
 Thunder Perfect Mind      06.02.2016 - 19:39:21 , level: 1, UP   NEW
http://www.ncbi.nlm.nih.gov/pubmed/26847689?dopt=Abstract
este to tusim nevyslo

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Thunder Perfect Mind
 Thunder Perfect Mind      22.11.2015 - 00:56:47 , level: 1, UP   NEW
https://journals.muni.cz/anthropologia_integra/article/view/2407/1973
http://www.ncbi.nlm.nih.gov/pubmed/26456305

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Thunder Perfect Mind
 Thunder Perfect Mind      08.11.2015 - 12:11:42 [6K] , level: 1, UP   NEW
Psychedelics and immunomodulation

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SYNAPSE CREATOR
 demian      19.10.2015 - 20:04:56 [15K] , level: 1, UP   NEW  HARDLINK
David Luke, ktory okrem ineho tento rok rozpraval aj na prednaskach Ceskej psychedelickej spolocnosti v Prahe a v Brne postol na fcb stranku UKC Psychedelics Society, tuto extremne zaujimavu ponuku:

"Looking to recruit volunteers for a study in London. Volunteers will receive a psychedelic for the exploration of creative problem solving.
We are looking for professionals and postgrads who work in science and technology related fields (e.g., engineering, maths, architecture, technology, programming, physics, biology, medicine) and who have a work-related technical problem they are looking to resolve.
Volunteers can be either experienced or inexperienced with psychedelics.
Please contact me if you are interested, or have contacts in these subject areas that can may be interested... thank you!'

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Thunder Perfect Mind
 Thunder Perfect Mind      12.10.2015 - 15:49:59 , level: 1, UP   NEW
Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

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Heaven and Hell
 Heaven and Hell      12.10.2015 - 21:16:39 , level: 2, UP   NEW
uuu nice. fulltext by nebol?

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Thunder Perfect Mind
 Thunder Perfect Mind      12.10.2015 - 21:23:26 , level: 3, UP   NEW
vyzera ze bol
http://www.researchgate.net/publication/270705914_Acute_Effects_of_Lysergic_Acid_Diethylamide_in_Healthy_Subjects

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Heaven and Hell
 Heaven and Hell      12.10.2015 - 22:06:37 , level: 4, UP   NEW
:D dik
your google-fu is strong with you :)

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Thunder Perfect Mind
 Thunder Perfect Mind      11.07.2015 - 00:34:26 [1K] , level: 1, UP   NEW
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464176/

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Heaven and Hell
 Heaven and Hell      11.07.2015 - 09:58:49 (modif: 13.07.2015 - 16:12:45), level: 2, UP   NEW !!CONTENT CHANGED!!
"the model generates specific predictions that can be tested" toto.

inak na prvy pohlad fajn clanok.

edit: tak som si precital cely ten clanok. pekna teoria. pracuje sa tam s netrivialnymi pojmami ako nahodna premenna a konecno rozmerny vektorovy priestor. tiez sa tam casto spomina entropia a pre mna je znamy pojem entropie z termodynamiky a nie mi uplne jasne co znamena entropia v informacnej teorii :). taktiez v momente ked sa zacalo pisat o EEG fMRI a inych diagnostickych metodach tak som sa stracal :) cize nejak kriticky sa ku tomu postavit zatial neviem :)

inak velmi mi to pripomina Jungovu teoriu komplexov. Len exaktnejsie spracovana t.j. presnejsie definovane pojmy a struktura komplexov :)

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Thunder Perfect Mind
 Thunder Perfect Mind      27.05.2015 - 22:37:59 [1K] , level: 1, UP   NEW
http://onlinelibrary.wiley.com/doi/10.1002/hbm.22833/abstract

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Thunder Perfect Mind
 Thunder Perfect Mind      28.05.2015 - 00:48:29 , level: 2, UP   NEW
The present results can be interpreted from a Bayesian
[Doya et al., 2011] and free-energy minimization [CarhartHarris
and Friston, 2010; Friston, 2010] perspectives.
According to this view, the brain is seen as an inference
machine making predictions about the world [von Helmholtz,
1866] and updating them based on experience and
more specifically “surprise” [Friston, 2010; Friston et al.,
2013]. From this perspective, any mental act, including
perception, is analogous to a scientific experiment: an
inference is made based on prior knowledge and then
modified or updated based on what is experienced
[Fletcher and Frith, 2009]. According to our observations,
psychedelics alter these core functions of the brain with
the effect of diminishing confidence or “certainty” about
perceived phenomena. It is intriguing to speculate about
the mechanics underlying this phenomenon and the present
results implicate a role for decreased PHC-neocortex
communication and/or decreased salience network integrity.

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cv::be
 cv::be      27.05.2015 - 22:45:12 [3K] , level: 2, UP   NEW
full text
https://dl.dropboxusercontent.com/u/28902/articles/Lebedev_et_al-2015-Human_Brain_Mapping.pdf

Embrace The Void!

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Thunder Perfect Mind
 Thunder Perfect Mind      16.04.2015 - 12:34:09 [1K] , level: 1, UP   NEW
http://www.scientificamerican.com/article/ayahuasca-psychedelic-tested-for-depression/

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Thunder Perfect Mind
 Thunder Perfect Mind      12.04.2015 - 14:09:48 , level: 1, UP   NEW
http://www.eurekalert.org/pub_releases/2015-02/lsuh-lhn020915.php

0000010100063533052119940758506607882645
SYNAPSE CREATOR
 demian      06.04.2015 - 23:18:27 [6K] , level: 1, UP   NEW  HARDLINK
Dalsi zaujimavy vyskum na Johns Hopkins University School of Medicine sa prave rozbieha a je mozne sa do neho zapojit prostrednicstvom online dotaznika.

Ak viete citat a pisat po anglicky a mate tak 45 az 60 minut casu a hlavne ste odpovedali 'ano' na otazku mizsie, tak sa mozete zapojit:
"Have you ever taken a hallucinogen and had a personal encounter with God or a Higher Power?"

Ciel vyskum:
We’re conducting an anonymous, web-based research study to characterize experiences of a personal encounter with something that someone might call “God” (e.g., the God of your understanding), “Higher Power,” or “Ultimate Reality.”

link na dotaznik a dalsie podrobnejsie informacie:
http://www.psychedelicencounteringthedivine.org/

3405key.jpg

0000010100063533052119940758506607881199
SYNAPSE CREATOR
 demian      04.04.2015 - 11:06:40 (modif: 24.04.2015 - 10:56:21) [25K] , level: 1, UP   NEW  HARDLINK !!CONTENT CHANGED!!
V CR vznika Ceska psychedelicka spolocnost, ktora chce nadviazat na vyskum psychedelik v CSR zo 60's.
Update: tu je docasna webstranka http://czeps.cz: je tam pripnuta aj (asi) posledna verzia manifestu.Plus da sa prihlasit do fora, ak budete mat chut nieco okomentovat.

Update II: ak by sa vam chcelo svojou trochou prispiet, tak potrebuju nejakych ludi, ktori im pomozu v Prahe pri vchode s listkami a podobne, aby to prebehlo co najmenej chaoticky.
Odmenou je dobry pocit a listok na akciu. Ked tak pls poslite mi spravu. Idealne co najskor.


Ako prvy ulovok sa im podarilo dotiahnut do CR Dr. Robina Carhart-Harrisa z UK, ktory po viac ako 40 rokoch znovuobnovil vyskum LSD na ludoch v UK.

Tema jeho prednasky sa bude dotykat jeho vyskumu a teda- funkční zobrazovací studie mozku s LSD a psilocybinem (psychoaktivní součást lysohlávek) a probíhající studii zaměřenou na studium antidepresivního účinku psilocybinu.

Uskutocnia sa dve prednasky v eng bez prekladania do cestiny. vstupne 80kc na pokrytie nakladov
Ak viete o ludoch, kotrych tato tema zaujima, tak prosim sirte informacie medzi nich

24.4. Brno - 6pm-8:30pm - sold out
https://www.facebook.com/events/290128974444424/290141181109870/
&
25.4. Praha 5pm - 7:30pm - sold out
https://www.facebook.com/events/407955402662550/
5725567.jpg

tu je este link na obsiahly clanok, ktory vysiel v Independent o Carhart-Harrisovi a jeho vyskumoch
http://www.independent.co.uk/news/people/dr-robin-carhartharris-is-the-first-scientist-in-over-40-years-to-test-lsd-on-humans--and-youre-next-9667532.html

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urza
 urza      04.11.2014 - 19:56:38 , level: 1, UP   NEW
Scientists Have Discovered Why Magic Mushrooms Are So 'Magical'

ZWZkODE3MDk1ZCMvSHNjbVF6TEs4MUxCYTQtMVpuVi1WSnNHRGhjPS8xeDQ6MTAzMng1NzgvODQweDQ2OC9maWx0ZXJzOnF1YWxpdHkoNzApL2h0dHA6Ly9zMy5hbWF6b25hd3MuY29tL3BvbGljeW1pYy1pbWFnZXMvY3BpcjNwNzljODRuNnp2Ym1mNWk2bHN6N2ptYzV4ZXZybnhmNzZmdHlibGlwamE1bXBhNHBpM2VuYmVlcXFnZy5qcGc=.jpg
http://mic.com/articles/102724/scientists-have-discovered-why-magic-mushrooms-are-so-magical

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Thunder Perfect Mind
 Thunder Perfect Mind      30.10.2014 - 00:42:11 (modif: 30.10.2014 - 00:46:07), level: 1, UP   NEW !!CONTENT CHANGED!!
Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction

Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells
... Our findings also point out a new biological role for dimethyltryptamines, which may act as systemic endogenous regulators of inflammation and immune homeostasis through the sigma-1 receptor.