Foldscope is the ultra-affordable paper microscope. It was designed to be portable and durable, while performing on par with conventional research microscopes (140X magnification and 2 micron resolution).

As a company, Foldscope Instruments Inc’s mission is to break down the price barrier between people & the curiosity and excitement of scientific exploration!

Through the purchase of our products, you directly support our mission and enable us to bring tools to communities around the world.
https://www.foldscope.com
https://en.wikipedia.org/wiki/Foldscope

Niečo trochu viac advanced:
https://www.planktonscope.org

https://www.inaturalist.org/
https://en.wikipedia.org/wiki/INaturalist

toto je moc pekne, na pozorovanie a identifikaciu druhov 'shazaam for nature', a je to neziskova vec ziaden startup bs
https://www.inaturalist.org/observations?place_id=44569

All things Biohacking.

zatial minimalisticky topic. Hadam sa casom rozsiri.

FB skupina, ktoru uz nejaky cas sledujem: Bio Hacker Tribe

Celkom pekna mapa: Why Nootropics?

In vivo production of psilocybin in E. coli
https://www.sciencedirect.com/science/article/pii/S109671761930309X

Highlights
• First example of psilocybin production in prokaryotic host.

• Genetic optimization shows high sensitivity to changes in transcriptional landscape.

• Pathway bottlenecks removed through fine-tuned optimization.

• Gram-scale production of psilocybin in Escherichia coli.


Abstract
Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising results in clinical trials for the treatment of addiction, depression, and post-traumatic stress disorder. The development of a psilocybin production platform in a highly engineerable microbe could lead to rapid advances towards the bioproduction of psilocybin for use in ongoing clinical trials. Here, we present the development of a modular biosynthetic production platform in the model microbe, Escherichia coli. Efforts to optimize and improve pathway performance using multiple genetic optimization techniques were evaluated, resulting in a 32-fold improvement in psilocybin titer. Further enhancements to this genetically superior strain were achieved through fermentation optimization, ultimIn vivo production of psilocybin in E. coliately resulting in a fed-batch fermentation study, with a production titer of 1.16 g/L of psilocybin. This is the highest psilocybin titer achieved to date from a recombinant organism and a significant step towards demonstrating the feasibility of industrial production of biologically-derived psilocybin.

rob rhinehart zije! (po tom co si odstranil crevny mikrobiom a zahadne odisiel z internetu aj rosa labs)

Investing in the Future of Food with Rob Rhinehart and Brian Frank
https://www.spreaker.com/user/10197011/investing-in-the-future-of-food-with-rob

Brian Frank (@bfrank) of FTW Ventures, and Rob Rhinehart (@robrhinehart) of Soylent, join Erik on this episode.

They discuss:

- Some of the most exciting developments in bioscience these days.

- The possibilities for biohacking and whether there is an “AWS for bioscience” emerging.

- The interplay of startups and incumbents in the space and how incumbents can be more helpful to the startup community.

- What is under- or over-hyped in the space.

- The existing big companies in food and bioscience and what will change in the next 5-10 years.

- The future of retail and how data can transform supply chains.

v piatok 22. 11. v paralelnej polis
https://www.facebook.com/events/1473050229500557/
Rozhodli sme sa zorganizovať neformálne stretnutia v úzkom kruhu nadšencov vedy. Na stretnutiach by sme sa radi venovali rôznym témam zo sveta biotechu a microbio.
Bude to taký ten typ neformálneho rozhovoru o vede, živote a biznise pri pohári dobrého vína alebo piva (optional).
Na BioWine nájdete parťákov, s ktorými takto viete stráviť príjemný “bio” večer :)

Na to, aby si sa mohol zúčastniť nemusíš byť odborník, stačí ti túžba spoznávať. Preferenčne je však event určený pre vedcov alebo študentov microbio odborov. Tešíme sa na teba!

P.S. Zabezpečíme nejaké nápoje, ale feel free priniesť čokoľvek, čo máš rád.

diy bio ba telegram group
https://t.me/diybiobratislava

Venuje sa tu niekto pestovaniu rias?

Founders of nonfood, Lucy Chinen & Sean Raspet discuss contemporary food supply chains and sustainable food futures, including the R&D of their own algae-based nonbar. Along the way, we address: monocultures, fear, skeuomorphic flavor, cellular agriculture, and the real cost of "all-natural." (w/ Caroline Busta, Daniel Keller, @LILINTERNET)

How biologists are creating life-like cells from scratch
https://www.nature.com/articles/d41586-018-07289-x
http://buildacell.io/
http://buildacell.io/engineering/build-a-cell/

https://soundcloud.com/a16z/damage-free-genome-editing-next-in-crispr-recent-journal-papers

Two recent scientific journal papers show what’s possible when CRISPR moves from cutting DNA tool to a full-fledged platform — expanding its toolkit for medicine across R&D, therapeutics, and diagnostics:

“Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration” in Nature — by Sanne Klompe, Phuc Vo, Tyler Halpin-Healy, and Samuel Sternberg (of Columbia University)

“RNA-guided DNA insertion with CRISPR-associated transposases” in Science — by Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan Schmid-burgk, Kira Makarova, Eugene Koonin, and Feng Zhang (of the Broad Institute)

What do these two papers — both about techniques for getting rid of the need to cut the genome to edit it — make possible going forward, given the ongoing shift of biology becoming more like engineering? Where are we in the wave of the genome engineering “developer community” building on top of CRISPR with a constantly growing suite of programmable functionalities? a16z bio general partner Jorge Conde and bio deal team partner Andy Tran chat with Hanne Tidnam about these trends — and these two papers — in this short internal hallway-style conversation, part of our new a16z Journal Club series.

Illustrated Guide to Home Biology Experiments: All Lab, No Lecture (DIY Science)



Experience the magic of biology in your own home lab. This hands-on introduction includes more than 30 educational (and fun) experiments that help you explore this fascinating field on your own. Perfect for middle- and high-school students and DIY enthusiasts, this full-color guide teaches you the basics of biology lab work and shows you how to set up a safe lab at home.

The Illustrated Guide to Home Biology Experiments is also written with the needs of homeschoolers firmly in mind, as well as adults who are eager to explore the science of nature as a life-long hobby. To get the most from the experiments, we recommend using this guide in conjunction with a standard biology text, such as the freely downloadable CK-12 Biology (ck-12.org).

Master the use of the microscope, including sectioning and staining
Build and observe microcosms, soda-bottle worlds of pond life
Investigate the chemistry of life from simple acids, bases, and buffers to complex carbohydrates, proteins, lipids, enzymes, and DNA
Extract, isolate, and observe DNA
Explore photosynthesis, osmosis, nitrogen fixation, and other life processes
Investigate the cell cycle (mitosis and cytokinesis)
Observe populations and ecosystems, and perform air and water pollution tests
Investigate genetics and inheritance
Do hands-on microbiology, from simple culturing to micro-evolution of bacteria by forced selection
Gain hands-on lab experience to prepare for the AP Biology exam
https://www.thehomescientist.com/manuals/Illustrated_Guide_to_Home_Biology_Experiments.pdf

uplne prve helloworld pokusy na agare

vzorka z drazdiaku po 1 dni:


po tyzdni+:



aspon 5 roznych kolonii


odtlacok zubnej kefky po 3 dnoch:


asi vydareny klon bez kontaminacie

https://www.appropedia.org/Hackteria
https://www.hackteria.org/wiki/Main_Page

Hackteria | Open Source Biological Art, DIY Biology, Generic Laboratory Infrastructure

Hackteria is an international network active since 2009 in the field of Open Source Biological Art. As a community platform hackteria tries to encourage the collaboration of scientists, hackers and artists to combine their experitise, write critical and theoretical reflections, share simple instructions to work with lifescience technologies and cooperate on the organization of workshops, temporary labs, hack-sprints and meetings. Hackteria is a network of people practicing DIY (do-it-yourself) and DIWO (do-it-with-others) biology with an interest in art, design and interdisciplinary cooperation. Hackteria operates on a global scale, and is based on a web platform and a wiki for sharing knowledge, which enable anyone to learn but also test different ways of hacking living systems. Hackteria is not based in a physical space, and its goal is to allow artists, scientists and hackers to collaborate and test various biohacking and bioart techniques outside the official laboratories and art institutions, basically anywhere in the world.

A Guide to DIYbio (updated 2019)

https://diybio.org/
https://sphere.diybio.org/

DIYbio.org was founded in 2008 with the mission of establishing a vibrant, productive and safe community of DIY biologists. Central to our mission is the belief that biotechnology and greater public understanding about it has the potential to benefit everyone.

https://pechblenda.hotglue.me/?transhackfeminism_en/
https://we.riseup.net/gynepunklab

Pechblenda lab was born out of the necessity to generate a space in Calafou (a community in a large former industrial space) for us to flourish, a non-patriarchal TransHackFeminist space where free knowledge springs from raw experimentation (electronic repairs, experiments with turbines, bioelectrochemistry, sound .... ) and self education.

Sick of the filthy dust, montonous and boring, of stagnant, unbreathable, competitive and excluding environments, of semi-free information which is actually totally controlled, power and decision of hunched up egocentric and infantile machos. Tired of repressed, impenetrable and homogenous bodies, we are resetting and migrating our bodies, modificable codes, lubricated and fluid, far from this sad landscape.

Tired of the useless and recursive manipulation of information, we study, construct and fail with all that is around us, with multiple, monstruous and hateful ends. From the expansion of information to the mutation of dispositives, we want to hack and recodify everything that is static and programmed by social and technological imposition.

PECHBLENDA is injected into our veins as an antidote to the heteropatriarchal arrogance that surrounds us. A disturbance, a transhackerfeminist electronic distortion.

We have found the place for our rituals,
we had dreamed it, written it in science fiction.

Now we live it with high voltage potentiality,
with the intensity of the shadows,
taking off together with desires in common,
with our differences.

The walls tremble and the water penetrates the tiny holes,
it expands like an unbreakable code exciting our neurons ;
we change the apparent path of events transiting antimelodies,
noise as arithmetic opening, outside of the calculated and homogenous,
noise feeding unlimited experimentation.

If we cant make noise its not our revolution.

Improvised performance creating and breaking codes, constructing hybrid machines.
Beat roots and obscure mutant landscapes that become the uncontrollable secretions of our desires. Electronautics and bioelectricity that chemically saturate the environment,
the acid smell of our hormones shakes the space,
resituated amongst cables, resistences, condensors and corrosive liquids.

Nature and technology are not different,
nature was to the witches what technoscience is to us, the cyborg witches.
We infiltrate the machine with our hands, sweat and disperse attention,
we prepare ourselves for inexact verification where the apparent error is desired,
where we fail, fuck, we are.

We are geek whores,
cyborg bitches.
We devour Haraway and Asimov,
Preciado and Python manuals,
Itziar Ziga and Neil Stephenson,
Margulis and Despentes,
hackmeetings and transfeminist workshps,
DIY electronics and sexual bricolage ;
we absorb PDFs of electronics theory y listen to psicofonias from around :
we read and design circuits,
and experiment with them in our bodies.

We scream noise and cyborg covens,
soldering and alchemy,
we spit out performances and install gnu-linux,
we love recycling and reparing with our breasts bared.

We laugh about everything, about ourselves ..
we detest the politically correct.
We parody what is socially understood to be feminine, what is supposed to be masculine.
We question the identity of assigned genders,
we exagerate it, ridiculise it.
Extremely sexual, ironic, sarcastic,
we love to party, to not sleep,
to take drugs if we feel like it,
to go with our friends
or to finish a circuit
or improvise an eternal noise jam.

Fed by pornoterrrorism and free culture,
we know how to use our claws and teeth if needs be.

https://brilliant.org/courses/computational-biology/

Computational biology merges the algorithmic thinking of the computer scientist with the problem solving approach of physics to address the problems of biology. Since the year 2000, an ocean of sequencing data has emerged that allows us to ask new questions.

Here we'll develop intuition for a selection of foundational problems in computational biology like genome reconstruction, sequence alignment, and building phylogenetic trees to look at evolutionary relationships. We also address certain physicochemical problems of molecular biology like RNA folding.
https://www.edx.org/course/principles-of-synthetic-biology

Do you like biology, biotechnology, or genetic engineering? Are you interested in computer science, engineering, or design? Synthetic Biology is an innovative field bringing together these subject areas and many more to create useful tools to solve everyday problems.

This introductory synthetic biology course starts with a brief overview of the field and then delves into more challenging yet exciting concepts. You will learn how to design your very own biological regulatory circuits and consider ways in which you can apply these circuits to real-world problems we face today.

From basic oscillators, toggle switches, and band-pass filters to more sophisticated circuits that build upon these devices, you will learn what synthetic biologists of today are currently constructing and how these circuits can be used in interesting and novel ways.

Join us as we explore the field of synthetic biology: its past, present, and promising future!

What you'll learn
Modern techniques in DNA assembly and regulation of gene expression and protein activity
How to design basic biological circuits
Principles for scaling up and creating large-scale biological circuits and regulatory networks
Basic ODE modeling of biological systems with MATLAB, introduction to Cello: genetic circuit design automation software

primer for synthetic biology (2007 draft)
https://s3-us-west-2.amazonaws.com/oww-files-public/3/3d/SB_Primer_100707.pdf

“Synthetic biology,” in the modern sense, means using engineering
principles to create functional systems based on the molecular machines and
regulatory circuits of living organisms. However, it also includes going beyond
them to develop radically new systems. At the very least, synthetic biology
represents a merger of molecular biology, genetic engineering and computer
science1
– and given the scale of the components that it works with, it also
qualifies as a form of nanotechnology. Students and others who wish to learn
about or – better still – to do synthetic biology often approach this exciting field
with only some of the background necessary to grasp its essentials. This threepart primer represents an effort to assist them in filling gaps in their knowledge.
Part I, “Molecular Biology for Novices,” summarizes the key aspects of
biochemistry and molecular biology that bear on synthetic biology. Part II,
“Engineering for Biologists,” introduces some basic engineering principles and
the most important tools used in synthetic biology. Part III, “Ethics for
Everyone,” briefly outlines the key ethical issues facing synthetic biology today.

https://waag.org/en/labs/open-wetlab
https://www.youtube.com/channel/UCVzZljBZA1AjfWBTrJuMSzA/videos

The Open WetLab is a leading place for bio-art, biodesign and do-it-together biology in the heart of Amsterdam. It works together with artists, designers, scientists, and hackers at public participation projects.

The Lab regularly organizes well-visited meet-ups. Beside that, artists and students can work in the lab as artistic researcher-in-residence and new biohackers are trained at the BioHack Academy: an international highly acclaimed course for biohackers, initiated by Pieter van Boheemen. The BioHack Academy learns individuals to build their own lab, create bio experiments, and teaches the basics of synthetic biology and critical reflection.
http://biohackacademy.github.io/

In BioHack Academy you design, build, use and share your own biolab. Each edition connects several groups around the world passionate about biotech and hacking.

Marcus Wohlsen - Biopunk: Solving Biotech's Biggest Problems in Kitchens and Garages
https://www.goodreads.com/book/show/9521936-biopunk

prehlad diy bio hnutia zo zaciatku dekady pre-crispr s pribehmi o vyznamnych outsideroch z historie biologie, magazinovy clanok kniznej dlzky idealny na zrychlene vypocutie http://audiobookbay.nl/audio-books/biopunk-solving-biotechs-biggest-problems-in-kitchens-and-garages-marcus-wohlsen/

https://www.theguardian.com/science/2019/may/15/cambridge-scientists-create-worlds-first-living-organism-with-fully-redesigned-dna

https://www.facebook.com/groups/diybiobratislava/
http://brmlab.cz/project/biolab/start

A Biopunk Manifesto by Meredith Patterson from Sophia Michelle Andren on Vimeo.

Scientific literacy is necessary for a functioning society in the modern age. Scientific literacy is not science education. A person educated in science can understand science; a scientifically literate person can *do* science. Scientific literacy empowers everyone who possesses it to be active contributors to their own health care, the quality of their food, water, and air, their very interactions with their own bodies and the complex world around them.

Society has made dramatic progress in the last hundred years toward the promotion of education, but at the same time, the prevalence of citizen science has fallen. Who are the twentieth-century equivalents of Benjamin Franklin, Edward Jenner, Marie Curie or Thomas Edison? Perhaps Steve Wozniak, Bill Hewlett, Dave Packard or Linus Torvalds -- but the scope of their work is far narrower than that of the natural philosophers who preceded them. Citizen science has suffered from a troubling decline in diversity, and it is this diversity that biohackers seek to reclaim. We reject the popular perception that science is only done in million-dollar university, government, or corporate labs; we assert that the right of freedom of inquiry, to do research and pursue understanding under one's own direction, is as fundamental a right as that of free speech or freedom of religion. We have no quarrel with Big Science; we merely recall that Small Science has always been just as critical to the development of the body of human knowledge, and we refuse to see it extinguished.

Research requires tools, and free inquiry requires that access to tools be unfettered. As engineers, we are developing low-cost laboratory equipment and off-the-shelf protocols that are accessible to the average citizen. As political actors, we support open journals, open collaboration, and free access to publicly-funded research, and we oppose laws that would criminalize the possession of research equipment or the private pursuit of inquiry.

Perhaps it seems strange that scientists and engineers would seek to involve themselves in the political world -- but biohackers have, by necessity, committed themselves to doing so. The lawmakers who wish to curtail individual freedom of inquiry do so out of ignorance and its evil twin, fear -- the natural prey and the natural predator of scientific investigation, respectively. If we can prevail against the former, we will dispel the latter. As biohackers it is our responsibility to act as emissaries of science, creating new scientists out of everyone we meet. We must communicate not only the value of our research, but the value of our methodology and motivation, if we are to drive ignorance and fear back into the darkness once and for all.

We the biopunks are dedicated to putting the tools of scientific investigation into the hands of anyone who wants them. We are building an infrastructure of methodology, of communication, of automation, and of publicly available knowledge.

Biopunks experiment. We have questions, and we don't see the point in waiting around for someone else to answer them. Armed with curiosity and the scientific method, we formulate and test hypotheses in order to find answers to the questions that keep us awake at night. We publish our protocols and equipment designs, and share our bench experience, so that our fellow biopunks may learn from and expand on our methods, as well as reproducing one another's experiments to confirm validity. To paraphrase Eric Hughes, "Our work is free for all to use, worldwide. We don't much care if you don't approve of our research topics." We are building on the work of the Cypherpunks who came before us to ensure that a widely dispersed research community cannot be shut down.

Biopunks deplore restrictions on independent research, for the right to arrive independently at an understanding of the world around oneself is a fundamental human right. Curiosity knows no ethnic, gender, age, or socioeconomic boundaries, but the opportunity to satisfy that curiosity all too often turns on economic opportunity, and we aim to break down that barrier. A thirteen-year-old kid in South Central Los Angeles has just as much of a right to investigate the world as does a university professor. If thermocyclers are too expensive to give one to every interested person, then we'll design cheaper ones and teach people how to build them.

Biopunks take responsibility for their research. We keep in mind that our subjects of interest are living organisms worthy of respect and good treatment, and we are acutely aware that our research has the potential to affect those around us. But we reject outright the admonishments of the precautionary principle, which is nothing more than a paternalistic attempt to silence researchers by inspiring fear of the unknown. When we work, it is with the betterment of the community in mind -- and that includes our community, your community, and the communities of people that we may never meet. We welcome your questions, and we desire nothing more than to empower you to discover the answers to them yourselves.

The biopunks are actively engaged in making the world a place that everyone can understand. Come, let us research together.

https://www.viennaopenlab.at/en/catalog/courses?ca=17%2F
intro workshopy za par eur

https://dab.genomefoundry.org/design_assemblies

EGF Design and Build is a project of the Edinburgh Genome Foundry to simplify the discovery and use of different assembly standards (such as EMMA, MoClo, Cyanogate), and to provide a simple portal to order constructs from the Foundry.

EGF DAB is open source and the code is on Github. It is part of the EGF Codons collection of open-source software for DNA assembly and Synthetic Biology.
https://edinburgh-genome-foundry.github.io/

https://www.wired.com/story/live-forever-synthetic-human-genome/

https://amino.bio/

http://biocurious.org/

8270115055_1d6dee9f4c_o
About
BioCurious is the World’s First Hackerspace for Bio, Built in the Heart of Silicon Valley.

We are a community of scientists, technologists, entrepreneurs, and amateurs who believe that innovations in biology should be accessible, affordable, and open to everyone.

Located in Santa Clara, CA, our co-working laboratory space and shared equipment is ideal for entrepreneurs, citizen scientists, hobbyists, and students.

https://www.reddit.com/r/researchchemicals/comments/b0a1u0/possibility_for_new_synthesis_pathways_using/