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The chemist Norman Pirie argued convincingly that leaf protein had much higher nutritional value than grain and bean proteins, and that it had the potential to be much more efficient economically, if it could be separated from the less desirable components of leaves.

The amino acid composition and nutritional value of leaf protein is similar to milk protein, which is understandable since cows produce milk from the amino acids produced in their rumens by bacteria digesting the leaves the cows have eaten. The bacteria perform the refining processes that Pirie believed could be done technologically, and they also degrade or detoxify the major toxins and allergens.

The nutrients produced in the cow's rumen are selectively absorbed into the cow's bloodstream, where the liver can further filter out any toxins before the amino acids and other nutrients are absorbed by the udder to be synthesized into milk. If cows are fed extremely bad diets, for example with a very large amount of grain, the filtering process is less perfect, and some allergens can reach the milk, but since sick cows are less profitable than healthy cows, dairies usually feed their cows fairly well.