Back in 2010, a team of researchers from Japan and the U.K. fed a slime mold with nutrients arranged to imitate the nodes of the Tokyo subway system. The resulting network was strikingly similar to the real thing, and sparked the emergence of what is now known as biologically inspired adaptive network design.

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https://www.linkedin.com/pulse/inside-japans-most-ambitious-plan-create-worlds-urban-tootoonchy?trk=articles_directory