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Tuesday, April 21, 2020 at 2:12 p.m.

No, Covid-19 is not just viral pneumonia


(Zurich) Zurich researchers analyzed the tissue of people who died from the new coronavirus. They believe it is systemic vascular inflammation and not pneumonia.
Illustrative photo.
Illustrative photo. (Photo: AFP)


Much more than pneumonia, COVID-19 is a systemic vascular inflammation, according to a study by researchers from Zurich. This explains why it causes so many cardiovascular problems and vital organ failures.

The first patients had mostly difficult-to-treat pneumonia, the University Hospital Zurich (USZ) said in a statement. Then, doctors later found more and more cases of cardiovascular disease and multiple organ failure with no apparent connection to pneumonia.

Zsuzsanna Varga's team at the USZ therefore examined tissue samples from deceased patients using a microscope and found that the inflammation affected the endothelium - the inner lining of blood vessels - of different organs.

The SARS-CoV-2 virus has been detected in the endothelium itself, where it kills the cells, then the affected tissues and organs. The researchers deduce that the virus attacks the immune system not by the lungs, but directly by the ACE2 receptors present in the endothelium, which thus loses its protective function.

All affected organs

"COVID-19 can affect the blood vessels of all organs," says Frank Ruschitzka, director of the USZ Cardiology Clinic, who now suggests calling this clinical picture "COVID-endothelitis."

It is a systemic inflammation of the blood vessels that can affect the heart, brain, lungs, kidneys or even the digestive tract. It causes serious micro-disturbances of the blood circulation which can damage the heart or cause pulmonary embolism, or even obstruct blood vessels in the brain or the gastrointestinal system, underlines the USZ.

If the endothelium of young patients defends itself well, this is not the case for the risk groups suffering from hypertension, diabetes or cardiovascular diseases, the common characteristic of which is reduced endothelial function.

Therapeutically, this means fighting the multiplication of the virus and at the same time protecting and stabilizing the vascular system of patients, concludes Professor Ruschitzka, quoted in the press release. These works are published in the British medical journal The Lancet.

A virus like no other

Other research published in the journal Science goes in the same direction, evoking a systemic disease and a virus which acts in a way different from all the other pathogens seen so far.

Kidney, brain and central nervous system damage has been reported, as have encephalitis, seizures and stroke in patients who have recovered. The intestines, rich in ACE2 receptors, are another front of attack: half of the patients suffer from diarrhea. The eyes and liver are also affected.





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original:
https://m.tdg.ch/articles/25930175


No, Covid-19 is not just viral pneumonia

Zurich researchers analyzed the tissue of people who died from the new coronavirus. They believe it is systemic vascular inflammation and not pneumonia.


original press release:
http://www.en.usz.ch/media/press-releases/pages/covid-19-endotheliitis.aspx