EVMS CRITICAL CARE COVID-19 MANAGEMENT PROTOCOL

Prophylaxis

While there is very limited data(and none specific for COVID-19), the following “cocktail” may have a role in the prevention/mitigation of COVID-19 disease, especially amongst the most vulnerable citizens in our community; i.e. those over the age of 60 years and those with medical comorbidities. While there is no high level evidence that this cocktail is effective; it is cheap, safe and should be readily available. So what is there to lose?

•Vitamin C 500mg BID and Quercetin 250-500 mg BID
•Zinc 75-100 mg/day(acetate, gluconateor picolinate). Zinc lozenges are preferred. After 1-2 months, reduce the dose to 30-50 mg/day.
•Melatonin (slow release): Begin with 0.3mg and increase as tolerated to 1-2 mg at night
•Vitamin D31000-4000u/day(optimal dose unknown). Likely that those with baseline low 25-OH vitamin D levels and those > living at 40olatitude will benefit the most.