#veda :: Remember, remember, the velvet November


node:	#veda
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parent:	Covid-19 / Novel Coronavirus (2019-nCoV)
owner:	Heaven and Hell
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created:	28.03.2020 - 18:24:13

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ponukaju vysvetlenie preco to dava dolu aj mladych a zdravych ludi

COVID-19 infection: the perspectives on immune responses

Overall, this synopsis is based on some clinical common sense. We propose some simple, but largely ignored, approaches to the treatment of COVID-19 patients (Fig. 1). We believe that the two-phase division is very important: the first immune defense-based protective phase and the second inflammation-driven damaging phase. Doctors should try to boost immune responses during the first, while suppressing it in the second phase. Since Vitamin B3 is highly lung protective, it should be used as soon as coughing begins. When breathing difficulty becomes apparent, hyaluronidase can be used intratracheally and at the same time 4-MU can be given to inhibit HAS2. Of course, HLA typing will provide susceptibility information for strategizing prevention, treatment, vaccination, and clinical approaches. We hope that some of the above ideas can be employed to help combat this deadly contagious disease of increasing incidence around the world.

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co je teda to ponuknute vysvetlenie pls? nejak som to tam nanasiel..no mozno mam len nedostatocnu znalost anglictiny a pochopenie textu

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ja tiez vela toho nerozumiem kedze je to uplne mimo mojho oboru, ale: rozdeluju COVID-19 na 2 fazy. prva pociatocna imunitna reakcia a telo sa snazi vysporiadat s cov2. tu su na tom horsie starsi ludia kedze maju napr nizsie hladiny NAD co ide z vekom a ine. ako liecba odporucaju boostovat imunitny system. 2. faza ked sa rozvinie ARDS v podstate ide proti tebe tvoj vlastny imunitny system. tu prave mlady a zdravy su na tom horsie. silnejsie imunitna reakcia. tu prave odporucaju potlacovat niecim co nazyvaju hyaluronidase.

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V tom paperi, na zaklade ktoreho tu odporucaju B3 pisu, ze

"These findings suggest that the development of pulmonary fibrosis induced by BLM was prevented through maintaining NAD by the administration of nicotinamide or niacin"

Co ak je pravda, tak za zvazenie by stal Nicotinamide Riboside, ktory "vyzera byt" na zvysenie hladiny NAD *podstatne* ucinnejsi, nez Niacin alebo Nicotinamide.

"vyzera byt", lebo afaik zatial neprebehlo az tak moc vyskumov. Na druhu stranu v tych zopar co boli to tak vyslo a vyzerali byt legit a dva z troch co som teraz namatkovo otvoril boli published v Nature Communications (treti v PLOS One. naspodok pastnem doi)

Problem je ale (ne)dostupnost. Je sice approved a komercne dostupny, no predava sa hrozne draho kvoli tomu, ze (ak sa dobre pamatam / zaoberal som sa nim pred par rokmi), ze aj ked nie je patentovany sam o sebe, tak jeho vyrobny postup patentovany je.

A sice sa nachadza aj v obyc B3 zmesiach, no vo velmi malych mnozstavach, a pri B3 zmesi je tiez nevyhoda, ze davkovanie je velmi obmedzene Niacinom, ktoreho len trochu vyssie davky maju vela negativnych ucinkov. (narozdiel od cisteho Nicotinamide alebo cisteho Nicotinamide Riboside)

doi:10.1038/ncomms12948
doi:10.1038/s41467-018-03421-7
doi:10.1371/journal.pone.0186459

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jj
dalsia moznost je nicotinamide mononucleotide (NMN). to tiez nie je najlacnejsia zalezitost ,ale aspon nie je patentovany a podla niektorych aj efektivnejsi ako nicotineamid riboside (NR).

asi od januara suplementujem NMN a resveratrol. resveratrol by mal tiez boostovat NAD. a este praktikujem intermittent fasting co by malo v kombinacii s NMN a resveratrolom este boostovat NAD.

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priebeh zapalu pluc je taky, ze mas virus pekne rozmnozeny v plucach, a poskodzuje nejaku tu membranu zrovna kde sa obmazuje krv na prekyslicenie, nasledkom coho sa ti zavodnuju pluca.

imunitny system este stale nevie rozoznat, voci comu bojovat. a ked dojde k tomu zavodneniu, tak imunitny system nabehne jak delo a zacne srotovat uz vsetko, co je v ceste, vratane tvojho tkaniva. dochadza vtedy k trvalemu poskodeniu pluc,takze aj kes to prezijes, asi uz si nezasportujes potom nikdy.

tipujem, ze o tom je ta druha faza potlacnia imunitnej reakcie, aby sa ziskal par dni cas a tie biele krvinky ci kery fras sa naucil rizpoznavat, co ma pozierat.

mam pocit, ze pluca samotne este maju nejaku autoregulaciu nejakou kuselinou, ktorou zabijaju v plucach infekcie. toto vzdy mierne aj poskodi zive tkanivo, ktore sa z toho ale zotavi (to je ten pripad azbestu, mineral co sa nikdy nerozlozi a teda ta kyselina postupne znici cele pluca).

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Sources of Vitamin B3. Good sources of vitamin B3 (niacin) include yeast, meat, poultry, red fish (e.g., tuna, salmon), cereals, legumes, and seeds. Milk, green leafy vegetables, coffee, and tea also provide some niacin

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s tym niacinom cituju tento paper
Effects of Nicotinamide and Niacin on Bleomycin-Induced Acute Injury and Subsequent Fibrosis in Hamster Lungs a podla abstraktu ide o udraziavane hladiny nicotinamide–adenine–dinucleotide. (NAD)

co je zaujimave tak ludia co sa venuju anti-agingu skunaju ako jednu z ciest prave udrziavanie NAD.