http://www.telegraph.co.uk/health/10371085/Party-drug-Ketamine-more-dangerous-than-previously-thought.html

ACMD member Dr Paul Dargan, consultant physician and clinical toxicologist at Guy's and St Thomas' NHS Foundation Trust, is preparing a report for the Home Secretary to be released shortly.

The main area of new evidence is around bladder toxicity, he said, amongst dependant users taking a high dose.
They become trapped in a “vicious cycle” where they take the drug to treat the pain caused by their addiction, leading to more bladder damage, incontinence, and possibly surgery to remove the bladder, which is then replaced by a bag to pass urine through.
Dr Dargan said users across the age-spectrum are having bladders removed, including people in their "20s, 30s, 40s and 50s".