The situation is not totally desperate. While some memes definitely manipulate us into collaborating on their replication in spite of our judging them useless or ugly or even dangerous to our health and welfare, many--most, if we are lucky--of the memes that replicate themselves do so not just with our blessings, but because of our esteem for them. I think there can be little controversy that the following memes are, all things considered, good from our perspective, and not just from their own perspective as selfish self-replicators:

such very general memes as:

cooperation

music

writing

calendars

education

environmental awareness

arms-reduction

and such particular memes as:

The Prisoner's Dilemma

The Marriage of Figaro

Moby Dick

long weekends

returnable bottles

the SALT Treaties

undergraduate major

Other memes are more controversial; we can see why they spread, and why, all things considered, we should tolerate them, in spite of the problems they cause for us:

colorization of classic films

teaching assistants

grade point averages

advertising on television

Hustler magazine

Still others are unquestionably pernicious, but extremely hard to eradicate:

anti-semitism

hijacking airliners

computer viruses

spray-can graffiti