The Grand Guignol (pronounced [gʁɑ̃ giɲɔl]) was a theatre (Le Théâtre du Grand-Guignol) in the Pigalle area of Paris (at 20 bis, rue Chaptal), which, from its opening in 1897 to its closing in 1962, specialized in naturalistic horror shows. The name is often used as a general term for graphic, amoral horror entertainment.

Since 1991, San Francisco's Thrillpeddlers theatre company has been performing English translations of plays originally shown at the Grand Guignol. They currently perform at their custom-designed theatre, The Hypnodrome.