14.december 2005
Roma 20:45 Basel
Strasbourg 20:45 Crvena Zvezda
Marseille 20:45 Dinamo Bucuresti
Heerenveen 20:45 Levski
Stuttgart 20:45 Rapid
PAOK 21:45 Rennes
Bolton 19:45 Sevilla
Guimarães 19:45 Beşiktaş

15.december 2005
Hamburg 18:30 Slavia
Monaco 18:30 CSKA Sofia
Palermo 20:45 Brøndby
Espanyol 20:45 M. Petach-Tikva
Lens 20:45 Sampdoria
Hertha 20:45 Steaua
Middlesbrough 19:45 Litex
AZ 20:45 Grasshoppers